updates / April 05, 2026 Mitochondrial dysfunction in Parkinson's Disease - ePrints Mitochondrial dysfunction in Parkinson's DiseaseLookup NU author(s): Paul Keane,Dr Marzena Kurzawa-Akanbi,Professor Peter Blain,Dr Christopher MorrisDownloadsAbstractParkinson’s disease (PD) is a progressive, neurodegenerative condition that has increasingly been linked with mitochondrial dysfunction and inhibition of the electron transport chain. This inhibition leads to the generation of reactive oxygen species and depletion of cellular energy levels, which can consequently cause cellular damage and death mediated by oxidative stress and excitotoxicity. A number of genes that have been shown to have links with inherited forms of PD encode mitochondrial proteins or proteins implicated in mitochondrial dysfunction, supporting the central involvement of mitochondria in PD. This involvement is corroborated by reports that environmental toxins that inhibit the mitochondrial respiratory chain have been shown to be associated with PD. This paper aims to illustrate the considerable body of evidence linkingmitochondrial dysfunction with neuronal cell death in the substantia nigra pars compacta (SNpc) of PD patients and to highlight the important need for further research in this area.Publication metadataAuthor(s): Keane PC, Kurzawa M, Blain PG, Morris CMPublication type: ArticlePublication status: PublishedJournal: Parkinson's DiseaseYear: 2011Volume: 2011Print publication date: 15/03/2011Date deposited: 07/01/2013ISSN (print): 2090-8083ISSN (electronic): 2042-0080Publisher: Hindawi Publishing CorporationURL: DOI: 10.4061/2011/716871PubMed id: 21461368AltmetricsShare
